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Its no longer recognized and targeted by the enzymes that would normally tear it apart

Mechanistically, lactylation of NEDD4 at lysine 33 decreases its binding affinity with Caspase-11 and the subsequent ubiquitination of Caspase-11, leading to non-canonical pyroptosis and advancing AILI

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Reddy AR, Chaitanya KV, Vivekanandan M (2004) Drought-induced responses of photosynthesis and antioxidant metabolism in higher plants

Effects of human growth hormone in men over 60 years old

Figure 5E) but did not differ by sex